AABC leadership encourages additional research, analysis and publications by investigators committed to exploring hypothesis on the aging brain. The primary aim of AABC is to create a repository of well-characterized longitudinal data collected from over 1,000 health individuals. Data will be used to generate within-participant brain trajectories and evaluate vulnerability and resilience to developing late life dementia. Legacy volunteers from the Human Connectome Project – Aging continue their research support by re-enrolling in AABC generating longitudinal follow up data spanning up to 10 years in some individuals.
Volunteers are cognitively and physically healthy at the time of enrollment. They complete in-person/imaging study visits every two years with remote follow up in the interim years. AABC collects demographic information (limited without PHI), plasma biomarkers, genetic, multi-omics, physiologic, health and cognitive data in conjunction with high-resolution cutting edge functional and structural neuroimaging data.
Within AABC, there are four primary projects:
Project 1: Examines the effects of stress and allostatic load, including inflammation, during the early adult period.
Project 2: Examines the effects of lifestyle behaviors on the trajectory of cognitive and brain changes during the mid adult period.
Project 3: Examines the effects of menopause transition/vasomotor symptoms during the mid adult period.
Project 4: Examines the clinical and neural indicators of resiliency and resistance to AD and ADRD in the later decades of adulthood.
Understanding the potential changes in brain trajectories associated with aging prior to the onset of neurodegenerative diseases such as Alzheimer’s disease and Alzheimer dementia related disorders is critical to identify potential future treatments.
Resource requests
To submit a request for AABC resources, please complete the following form.
Research supported by…
This research is supported by National Institutes of Aging (NIA) of the National Institutes of Health (NIH) under award numbers U19AG073585 (Aging Adult Vulnerability and Resiliency in the Aging Adult Brain Connectome (AABC). AABC is a continuation of the important Human Connectome Project in Aging grant also funded by the NIH under award U01AG052564-01.
Learn more about our authorship and acknowledgement guidelines:
Questions
For general questions regarding AABC data sharing and authorship policies, please contact the project manager.