Project 4: Low Versus High Function in the Oldest Old

The overarching aim of David Salat’s work is to understand mechanisms of neural disease and to implement novel approaches to reduce the impact of disease on the brain, cognition and clinical status. Clinically, there are two main clinical foci to his research. At the MGH Martinos Center, he directs the Brain Aging and Dementia Laboratory, with a research focus on understanding systemic and neural mechanisms of age-associated cognitive decline and dementia. A major focus of this work is to understand cerebrovascular contributions to brain aging and dementia. He is also the MGH site Principal Investigator for the Human Connectome Project – Mapping the Human Connectome with Typical Aging multisite effort.